PANTA RHEI: EVERYTHING FLOWS… IN MICROREACTORS AND IN BEATING HEARTS
A macroscopic artist impression of the hydrodynamics in microreactors.
Tailor-made microreactors, 3D printed with high resolution printheads.
Continuous flow process development on demand.
Flow chemistry, in its most basic sense, is defined as performing a chemical transformation in a continuous manner by pumping the reagents through a microreactor. In recent decades, flow chemistry gained a lot of interest both in academia and industry. Its increasing popularity is due to a lot of advantages over classical flask chemistry, such as safety aspects. Especially regarding the scalability of photo- and electrochemical reactions, flow chemistry offers numerous advantages.
Microreactors are used in the pharmaceutical industry in the drug discovery process, but also for the synthesis of nanoparticles, polymers and bio-substances in the fields of medicine and life sciences. Since the channels in microreactors have dimensions below 1 mm, 3D inkjet printing provides us with a high resolution printing technique that enables us to design and produce microreactors in a very flexible way. In the cabinet we show some samples that were designed and 3D printed by ChemStream with self-developed inks.
Detail of a 3D printed microreactor
Experimental setup of a flow reactor in which the chemical reaction is triggered by UV-light
Some of flow chemistry and microreactor technology’s main advantages are:
Increased mixing efficiency
Enhanced temperature control (better heating/cooling)
Shorter reaction times (improved kinetics)
Easy access to high pressures
Possibility of performing ‘forbidden’ chemistry by in situ generation
Controlled scaling factors (simple to scale up)
More efficient biphasic reaction (such as gas-liquid ones)
Enhanced safety ratings
ChemStream has the expertise in house to develop continuous flow syntheses for its customers, from scratch or for the scaling up of existing non-continuous processes.
More about this subject can be found here